Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Nov 30;14(11):2863-2866.
doi: 10.21037/tp-2025-616. Epub 2025 Nov 26.

Beyond the trial data: why conservative oxygenation targets require nuanced implementation in pediatric critical care

Mohammed A Shaik  1 , Christopher Horvat  1
Affiliations
Editorial

Beyond the trial data: why conservative oxygenation targets require nuanced implementation in pediatric critical care

Mohammed A Shaik et al. Transl Pediatr. .
No abstract available

Keywords: Oxygen; clinical trial; critical care.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-616/coif). The authors have no conflicts of interest to declare.

Comment on

References

    1. Lilien TA, Groeneveld NS, van Etten-Jamaludin F, et al. Association of Arterial Hyperoxia With Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis. JAMA Netw Open 2022;5:e2142105. 10.1001/jamanetworkopen.2021.42105 - DOI - PMC - PubMed
    1. Pelletier JH, Ramgopal S, Horvat CM. Hyperoxemia Is Associated With Mortality in Critically Ill Children. Front Med (Lausanne) 2021;8:675293. 10.3389/fmed.2021.675293 - DOI - PMC - PubMed
    1. Ramgopal S, Dezfulian C, Hickey RW, et al. Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit. JAMA Netw Open 2019;2:e199812. 10.1001/jamanetworkopen.2019.9812 - DOI - PMC - PubMed
    1. Louman S, van Stralen KJ, Pijnenburg MWH, et al. Oxygen saturation targets for children with respiratory distress: a systematic review. ERJ Open Res 2023;9:00256-2023 . 10.1183/23120541.00256-2023 - DOI - PMC - PubMed
    1. Briggs S, Gupta V, Thakkar N, et al. Decreasing Goal Oxygen Saturations in Bronchiolitis Is Associated With Decreased Length of Stay. Hosp Pediatr 2023;13:688-94. 10.1542/hpeds.2022-007020 - DOI - PubMed