From surgery to systemic therapy in von Hippel-Lindau disease: insights from extended follow-up of LITESPARK-004
- PMID: 41368258
- PMCID: PMC12683487
- DOI: 10.21037/tau-2025-637
From surgery to systemic therapy in von Hippel-Lindau disease: insights from extended follow-up of LITESPARK-004
Keywords: Von Hippel-Lindau disease (VHL disease); belzutifan; hypoxia-inducible factor-2α inhibition (HIF-2α inhibition); renal cell carcinoma (RCC).
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-2025-637/coif). L.M.T. reports research funding (institution) from Seagen, Merck, and Erasca; travel support from ASCO Merit Award; advisory board/consultant role from American Journal of Managed Care’s Institute for Value-Based Medicine; and honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from OncLive/MJH Life Sciences and CancerNetwork. S.S.T. reports a consulting role from FirstWord, Bristol-Myers Squibb, AVEO Oncology and Exelixis; honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from OncLive/MJH Life Sciences, Targeted Oncology, CancerNetwork, and Topline Bio; support for attending meetings/travel from DAVA Oncology and KidneyCAN; and research funding (institution) from Xencor, Merck, AVEO Oncology, Bristol-Myers Squibb, Exelixis, Pfizer, Iovance Biotherapeutics and HiberCell. The authors have no other conflicts of interest to declare.
Comment on
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Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study.Lancet Oncol. 2025 May;26(5):571-582. doi: 10.1016/S1470-2045(25)00099-3. Epub 2025 Apr 12. Lancet Oncol. 2025. PMID: 40228516 Clinical Trial.
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