Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Sep;27(3):359-64.

Glucocorticoid inhibition of antigen-evoked histamine release from human skin

M W Greaves, V M Plummer

Glucocorticoid inhibition of antigen-evoked histamine release from human skin

M W Greaves et al. Immunology. 1974 Sep.

Abstract

Prednisolone causes a dose-related inhibition of antigen-evoked histamine release from IgE-sensitized human skin in vitro. The effective concentrations are of the same order as are achieved in plasma therapeutically.

Analysis of prednisolone inhibition shows that it acts on the second histamine release stage, antigen—antibody combination being unaffected.

In contrast with the traditional view, our results show that, at least in human skin, glucocorticoids can inhibit antigen-evoked histamine release.

PubMed Disclaimer

References

    1. Bull Johns Hopkins Hosp. 1950 Nov;87(5):354-86 - PubMed
    1. Int Arch Allergy Appl Immunol. 1973;44(6):797-803 - PubMed
    1. Arch Surg. 1972 Aug;105(2):230-6 - PubMed
    1. Immunology. 1972 Aug;23(2):239-48 - PubMed
    1. Annu Rev Med. 1962;13:241-8 - PubMed

LinkOut - more resources