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Case Reports
. 2025 Dec;25(4):385-388.
doi: 10.7704/kjhugr.2025.0061. Epub 2025 Dec 4.

An Unusual Cause of Hematemesis in a Patient Previously Treated for Cholangiocarcinoma

Tae-Woo Kim  1 , Byung-Wook Kim  1 , Joon Sung Kim  1
Affiliations
Case Reports

An Unusual Cause of Hematemesis in a Patient Previously Treated for Cholangiocarcinoma

Tae-Woo Kim et al. Korean J Helicobacter Up Gastrointest Res. 2025 Dec.

Abstract

A 75-year-old woman presented with hematemesis and a history of perihilar cholangiocarcinoma treated with left lobectomy, caudate lobectomy, and Roux-en-Y hepaticojejunostomy. Esophagogastroduodenoscopy revealed a 3×3-cm polypoid lesion accompanied by active bleeding. Biopsy revealed adenocarcinoma, favoring metastasis over primary gastric cancer, considering the patient's medical history and previous endoscopic evaluations. Despite endoscopic hemostasis, anemia persisted, prompting laparoscopic wedge resection of the gastric mass. Here, we present a rare case of gastric metastasis from cholangiocarcinoma, underscoring the unusual presentation of upper gastrointestinal bleeding caused by a gastric tumor in a patient previously treated for cholangiocarcinoma.

Keywords: Cholangiocarcinoma; Hematemesis; Metastasis.

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Conflict of interest statement

Conflicts of Interest

The authors have no financial conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Abdominopelvic computed tomography shows a 38.54 mm lesion in the gastric fundus.
Fig. 2.
Fig. 2.
A 3×3 cm polypoid mass with active bleeding in the gastric fundus.
Fig. 3.
Fig. 3.
Successful hemostasis with hemostatic powder.
Fig. 4.
Fig. 4.
Optical microscopy (H&E, ×100) of gastric biopsy.
Fig. 5.
Fig. 5.
The resected gastric tumor specimen. E, esophagus side.
See this image and copyright information in PMC

References

    1. Brindley PJ, Bachini M, Ilyas SI, et al. Cholangiocarcinoma. Nat Rev Dis Primers. 2021;7:65. - PMC - PubMed
    1. Wakahara T, Tsukamoto T, Kitamura S, et al. Metastatic colon cancer from intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2005;12:415–418. - PubMed
    1. Kim EM, Lee BS, Moon HS, et al. Distal cholangiocarcinoma with gastric metastasis mimicking early gastric cancer. Gut Liver. 2009;3:222–225. - PMC - PubMed
    1. Wang C, Zhang B, Peng R, et al. Cholangiocarcinoma presenting as dysphagia and misdiagnosed as gastritis: a case report. BMC Gastroenterol. 2022;22:78. - PMC - PubMed
    1. Zhu Q, Zhai S, Ge E, et al. Intrahepatic cholangiocarcinoma with gastric metastasis misdiagnosed as primary gastric cancer: a case report and literature review. Front Oncol. 2022;12:997735. - PMC - PubMed

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