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. 1974 Oct;14(4):918-23.
doi: 10.1128/JVI.14.4.918-923.1974.

Temperature-sensitive mutants of murine leukemia virus. IV. Further physiological characterization and evidence for genetic recombination

J R Stephenson, S R Tronick, S A Aaronson

Temperature-sensitive mutants of murine leukemia virus. IV. Further physiological characterization and evidence for genetic recombination

J R Stephenson et al. J Virol. 1974 Oct.

Abstract

Several temperature-sensitive mutants of the Rauscher strain of murine leukemia virus representing three distinct physiological groups have been further characterized. Genetic recombination between different pairs of these mutants has been demonstrated. Several representative genetic recombinants were isolated and shown to replicate equally well at the permissive (31 C) and nonpermissive (38 C) temperatures and to have serological characteristics of the wild-type parental virus. Alternative models for the mechanisms involved in recombination between type C RNA viruses are discussed.

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