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. 1974 Dec 1;140(6):1660-75.
doi: 10.1084/jem.140.6.1660.

Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice

K B Bechtol, J H Freed, L A Herzenberg, H O McDevitt

Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice

K B Bechtol et al. J Exp Med. .

Abstract

In order to further delineate the mechanisms underlying genetic unresponsiveness, tetraparental mice were constructed from immune response-1A gene high responder and low responder parental genotypes, then were immunized with poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys ((T,G)-A--L). An analysis of the total serum allotype mixture and of the antigen-binding capacity of the separated allotypes demonstrated that in the milieu of a tetraparental mouse, both high and low responder B cells could be stimulated equally to produce identical high titered anti-(T,G)-A--L responses. Furthermore, these studies show that effective stimulation could occur across a histocompatibility disparity.

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References

    1. J Exp Med. 1965 Sep 1;122(3):517-31 - PubMed
    1. J Exp Med. 1966 May 1;123(5):859-79 - PubMed
    1. Transplantation. 1967 Nov;5(6):1484-95 - PubMed
    1. J Immunol. 1968 Mar;100(3):485-92 - PubMed
    1. J Exp Med. 1968 Jul 1;128(1):1-11 - PubMed