Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Nov;14(5):1274-80.
doi: 10.1128/JVI.14.5.1274-1280.1974.

Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30

H Ikeda, T Pincus, T Yoshiki, M Strand, J T August, E A Boyse, R C Mellors

Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30

H Ikeda et al. J Virol. 1974 Nov.

Abstract

Antisera to purified structural proteins of Rauscher murine leukemia virus, the major envelope glycoprotein, gp69/71, and the major internal protein, p30, were studied by immunofluorescence of viable and fixed virus-infected cells and by virus neutralization. Group-specific and type-specific determinants of gp69/71 were demonstrated by immunofluorescence and virus neutralization tests, indicating that these determinants are located in the cytoplasm and probably on the cell surface as well as on virus envelope. Antisera against p30 showed anti-group and anti-interspecies activities by immunofluorescence with no virus-neutralizing activity. Both antigenic determinants of gp69/71 were sensitive to guanidine-hydrochloride and to a lesser degree to ether treatment, whereas the group-specific determinants of p30 were relatively stable to these treatments.

PubMed Disclaimer

References

    1. Cancer Res. 1965 Jul;25(6):813-9 - PubMed
    1. Fed Proc. 1965 Sep-Oct;24(5):1009-17 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 May;53(5):931-8 - PubMed
    1. Virology. 1969 Feb;37(2):189-202 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Jul;63(3):753-8 - PubMed

LinkOut - more resources