Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Sep;71(9):3542-4.
doi: 10.1073/pnas.71.9.3542.

Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon

R M Friedman, J M Ramseur

Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon

R M Friedman et al. Proc Natl Acad Sci U S A. 1974 Sep.

Abstract

Treatment of AKR cells that had spontaneously become procedures of a murine leukemia virus with a partially purified mouse interferon (> 5 x 10(7) international mouse reference units per mg of protein) inhibited endogenous virus production. This inhibitory effect decreased over a 72-hr period in a manner similar to interferon-induced antiviral activity directed against vesicular stomatitis virus in AKR cells. Despite the inhibitory effect of interferon on infectious murine leukemia virus and viral reverse transcriptase (RNA-dependent DNA polymerase) titers in the culture fluids, intracellular levels of viral groups-specific antigens were significantly increased. These results suggest that interferon treatment in AKR cells inhibited the assembly or release of the virus.

PubMed Disclaimer

References

    1. Nature. 1969 Aug 23;223(5208):845-6 - PubMed
    1. Virology. 1970 Dec;42(4):1136-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Feb;68(2):299-302 - PubMed
    1. Nature. 1971 Jan 29;229(5283):318-21 - PubMed
    1. Proc Soc Exp Biol Med. 1971 Jul;137(3):1075-81 - PubMed

LinkOut - more resources