Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Sep;71(9):3588-92.
doi: 10.1073/pnas.71.9.3588.

Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity

D G Marsh, W B Bias, K Ishizaka

Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity

D G Marsh et al. Proc Natl Acad Sci U S A. 1974 Sep.

Abstract

Studies of the distribution of total serum immunoglobulin E levels in nonallergic and allergic populations defined a cut-off point between low and high immunoglobulin E at 95 U/ml, based on Mendelian recessive inheritance of high immunoglobulin E level. Subsequent investigations of the distribution of total serum immunoglobulin E levels in 28 allergic families confirmed the recessive hypothesis. The results of quantitative skin tests in eight families, performed with between five and eight highly purified grass and ragweed pollen allergens per family, demonstrate that the immunoglobulin E-regulating gene exerts a profound effect on specific immunoglobulin E-mediated sensitivity, often masking the effect of HL-A associated immune response genes.

PubMed Disclaimer

References

    1. Int Arch Allergy Appl Immunol. 1968;34(1):1-8 - PubMed
    1. J Allergy. 1968 Dec;42(6):330-63 - PubMed
    1. Transplantation. 1969 Mar;7(3):220-3 - PubMed
    1. Biochemistry. 1969 Mar;8(3):980-9 - PubMed
    1. Int Arch Allergy Appl Immunol. 1969;36(3):219-32 - PubMed