Effects of X-rays or aseptic inflammatory reaction on the circadian rhythm of tyrosine aminotransferase in mouse liver (TAT activity of mouse liver)

Abstract

Effects of x-rays or aseptic inflammatory reaction on the circadian rhythm of tyrosine aminotransferase in mouse liver (TAT activity of mouse liver). Acta physiol. pol., 1979, 30 (4): 479--487. The circadian rhythm of tyrosine aminotransferase (TAT) was investigated during 48 hours in the liver of mice subjected to: -- subcutaneous inflammatory reaction -- ionizing radiation. The cyclic changes in the circadian enzyme activity were described with a harmonic function. In relation to the control mice in the experimental mice statistically significant changes were demonstrated in the activity of tyrosine aminotransferase associated with desynchronization of the circadian TAT rhythm, particularly evident in the first hours of the first day of the experiment. The functions of enzyme activity changed in the second 24-hour period showed, both qualitatively and quantitatively, a tendency for a gradual return of normal TAT activity in the 24-hour periods.