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. 1974 Dec;71(12):5014-6.
doi: 10.1073/pnas.71.12.5014.

The presence of I-region-associated antigens on B cells in molecules distinct from immunoglobulin and H-2K and H-2D

E R Unanue, M E Dorf, C S David, B Benacerraf

The presence of I-region-associated antigens on B cells in molecules distinct from immunoglobulin and H-2K and H-2D

E R Unanue et al. Proc Natl Acad Sci U S A. 1974 Dec.

Abstract

The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The complexes of I-anti-I-region-associated antigens were found to be distributed throughout the lymphocyte surface both at 4 degrees and 37 degrees . In about two-thirds of the lymphocytes the complexes redistributed into caps after incubation with a second ligand (an anti-mouse immunoglobulin). The I-region specificities were in molecules distinct from immunoglobulin or from the molecules coded by the H-2K and H-2D regions.

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References

    1. Proc Natl Acad Sci U S A. 1974 Mar;71(3):648-52 - PubMed
    1. J Immunol. 1974 Jul;113(1):181-8 - PubMed
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