Approach to Quality Control Used for the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis

Affiliations

¹ Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
² Renal, Electrolyte and Hypertension Division, Department of Medicine, Department of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
³ Nephrology Division, Department of Medicine, NYU Grossman School of Medicine, New York, New York.
⁴ Clinical Research Collaboration Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Department of Medicine, George Washington University, Washington, DC.
⁶ Yale School of Public Health, New Haven, Connecticut.
⁷ Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
⁸ Division of Nephrology, University of Illinois Hospital and Health Sciences Center, Chicago, Illinois.
⁹ Department of Population Health Nursing Science, University of Illinois Chicago, Chicago, Illinois.
¹⁰ Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
¹¹ Minneapolis, Minnesota.
¹² Division of Nephrology, Hennepin Healthcare and Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Sagar U Nigwekar et al. Clin J Am Soc Nephrol. 2025.

. 2025 Dec 2.

doi: 10.2215/CJN.0000000970. Online ahead of print.

¹ Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
² Renal, Electrolyte and Hypertension Division, Department of Medicine, Department of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
³ Nephrology Division, Department of Medicine, NYU Grossman School of Medicine, New York, New York.
⁴ Clinical Research Collaboration Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Department of Medicine, George Washington University, Washington, DC.
⁶ Yale School of Public Health, New Haven, Connecticut.
⁷ Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
⁸ Division of Nephrology, University of Illinois Hospital and Health Sciences Center, Chicago, Illinois.
⁹ Department of Population Health Nursing Science, University of Illinois Chicago, Chicago, Illinois.
¹⁰ Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
¹¹ Minneapolis, Minnesota.
¹² Division of Nephrology, Hennepin Healthcare and Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

No abstract available

Keywords: ESKD; hyperphosphatemia; vascular calcification.

References

1. Strippoli GF, Craig JC, Schena FP. The number, quality, and coverage of randomized controlled trials in nephrology. J Am Soc Nephrol. 2004;15(2):411–419. doi:10.1097/01.ASN.0000100125.21491.46 - DOI
1. Inrig JK, Califf RM, Tasneem A, et al. The landscape of clinical trials in nephrology: a systematic review of Clinicaltrials.gov. Am J Kidney Dis. 2014;63(5):771–780. doi:10.1053/j.ajkd.2013.10.043 - DOI
1. Dember LM, Hsu JY, Mehrotra R, et al. Pain coping skills training for patients receiving hemodialysis: the HOPE consortium randomized clinical trial. JAMA Intern Med. 2025;185(2):197–207. doi:10.1001/jamainternmed.2024.7140 - DOI
1. Dember LM, Hsu JY, Bernardo L, et al. The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis. Contemp Clin Trials. 2024;136:107409. doi:10.1016/j.cct.2023.107409 - DOI
1. Mehrotra R, Cukor D, McCurry SM, et al. Effectiveness of existing insomnia therapies for patients undergoing hemodialysis: a randomized clinical trial. Ann Intern Med. 2024;177(2):177–188. doi:10.7326/M23-1794 - DOI