Metal overload synergy induces cell death in gastric cancer
- PMID: 41420102
- DOI: 10.1038/s41418-025-01651-z
Metal overload synergy induces cell death in gastric cancer
Conflict of interest statement
Competing interests: PAL declares a financial conflict of interest as a cooperation partner of, advisor to, founder, shareholder, and patent inventor of Abalos Therapeutics GmbH, developing an Arenavirus-based cancer therapy.
References
-
- Luan M, Feng Z, Zhu W, Xing Y, Ma X, Zhu J, et al. Mechanism of metal ion-induced cell death in gastrointestinal cancer. Biomed Pharmacother. 2024;174:116574. https://doi.org/10.1016/j.biopha.2024.116574 . - DOI - PubMed
-
- Luan M, Zhu W, Feng Z, Jing F, Xing Y, Ma X, et al. MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer. Cell Death and Differ. 2025.
-
- Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185:2401–21. https://doi.org/10.1016/j.cell.2022.06.003 . - DOI - PubMed - PMC
-
- Minotti G, Aust SD. The role of iron in oxygen radical mediated lipid peroxidation. Chem Biol Interact. 1989;71:1–19. https://doi.org/10.1016/0009-2797(89)90087-2 . - DOI - PubMed
-
- Turcu AL, Versini A, Khene N, Gaillet C, Cañeque T, Müller S, et al. DMT1 inhibitors kill cancer stem cells by blocking lysosomal iron translocation. Chemistry. 2020;26:7369–73. https://doi.org/10.1002/chem.202000159 . - DOI - PubMed
Publication types
Grants and funding
- LA2885/8-1/Deutsche Forschungsgemeinschaft (German Research Foundation)
- 9B797/Volkswagen Foundation (VolkswagenStiftung)
- 14LW0450/Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
- Forschungskommission/Heinrich Heine University Düsseldorf | Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf (Medical Faculty, Heinrich-Heine-University)
- MOI/Jürgen Manchot Stiftung (Jürgen Manchot Foundation)
LinkOut - more resources
Full Text Sources
