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. 2025 Dec 22;14(1):e71732.
doi: 10.1002/ccr3.71732. eCollection 2026 Jan.

Persistent Burkholderia cepacia Bacteremia in Reconstructive Surgery: Resistance to Ceftazidime/Avibactam and Co-Trimoxazole With Risk of Infective Endocarditis-A Case Report

Chukwuka Elendu  1 , Dependable C Amaechi  2 , Tochi C Elendu  3 , Emmanuel C Amaechi  4 , Ijeoma D Elendu  3 , Adaobi S Ikedilo  5
Affiliations

Persistent Burkholderia cepacia Bacteremia in Reconstructive Surgery: Resistance to Ceftazidime/Avibactam and Co-Trimoxazole With Risk of Infective Endocarditis-A Case Report

Chukwuka Elendu et al. Clin Case Rep. .

Abstract

Persistent Burkholderia cepacia bacteremia in soft tissue infections creates diagnostic and therapeutic challenges due to its resistance profile and potential for endovascular involvement. Early culture-guided therapy, multidisciplinary coordination, and vigilance for complications, such as infective endocarditis, are essential for achieving favorable outcomes in reconstructive surgical settings.

Keywords: Burkholderia cepacia; bacterial multidrug resistance; sepsis; skin grafting; wound infection.

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Conflict of interest statement

The views expressed in this report are solely those of the author(s) and do not represent the official positions of any affiliated institutions.The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Chronic leg ulcer before surgical intervention, highlighting the extent of tissue damage and surrounding inflammation.
FIGURE 2
FIGURE 2
Autogenous split‐thickness skin grafting procedure performed on the chronic leg ulcer.
FIGURE 3
FIGURE 3
Postoperative appearance of the skin graft demonstrating early integration with surrounding tissue.
FIGURE 4
FIGURE 4
Antibiotic susceptibility profile of the Burkholderia cepacia complex isolate showing resistance and intermediate susceptibility to commonly used antimicrobials.
FIGURE 5
FIGURE 5
Daily temperature and CRP trends throughout the patient's hospitalization.
FIGURE 6
FIGURE 6
Healed skin graft site at 2‐week follow‐up, showing excellent cosmetic outcome and full graft integration without evidence of infection or rejection.
See this image and copyright information in PMC

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