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. 1973 Apr;27(4):283-90.
doi: 10.1038/bjc.1973.35.

The effects of aflatoxin B 1 in vivo on membrane--ribosome association

D J Williams, R P Clark, B R Rabin
Free PMC article

The effects of aflatoxin B 1 in vivo on membrane--ribosome association

D J Williams et al. Br J Cancer. 1973 Apr.
Free PMC article

Abstract

The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.

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