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. 1973 May 18;180(4087):757-8.
doi: 10.1126/science.180.4087.757.

Histamine: effect on self-stimulation

C K Cohn, G G Ball, J Hirsch

Histamine: effect on self-stimulation

C K Cohn et al. Science. .

Abstract

When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.

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