Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Dec 17:13:1727134.
doi: 10.3389/fped.2025.1727134. eCollection 2025.

Lipid metabolism abnormalities in pediatric abdominal solid malignant tumors: a comprehensive review

Qiang Hao #  1   2   3 , Lu Han #  1   2   3 , Wenrui Mi #  1   2   3 , Tingting Hu  4 , Aiqin Lin  2 , Jie Liu  1
Affiliations
Review

Lipid metabolism abnormalities in pediatric abdominal solid malignant tumors: a comprehensive review

Qiang Hao et al. Front Pediatr. .

Abstract

Pediatric abdominal solid tumors mainly include neuroblastoma, nephroblastoma, hepatoblastoma, and rhabdomyosarcoma. Although significant progress has been made in the treatment of these tumors with the combination of surgery and chemotherapy, the treatment outcomes for some patients remain unsatisfactory, and the mortality rate for late-stage patients is still high. The diagnosis and treatment of abdominal solid tumors remain one of the key challenges in pediatric oncology. Numerous studies have found that lipid metabolism abnormalities in tumor tissues and cells lead to a significant increase in lipid levels, promoting cell proliferation, tumor progression, and chemoresistance. This review focuses on the recent advances in the study of lipid metabolism abnormalities in pediatric abdominal solid tumors, aiming to provide a theoretical basis for the treatment of these tumors.

Keywords: abdominal; lipid metabolism; pediatric; solid malignant tumor; update.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Lipid metabolism abnormalities in pediatric abdominal solid malignant tumors.
See this image and copyright information in PMC

References

    1. Zierke K, Boettcher M, Behrendt P, Najem S, Zapf H, Reinshagen K, et al. Health-related quality of life and mental health of parents of children with pediatric abdominal tumors. Children (Basel). (2024) 11(8):998. 10.3390/children11080998 - DOI - PMC - PubMed
    1. Perotti D, Williams RD, Wegert J, Brzezinski J, Maschietto M, Ciceri S, et al. Hallmark discoveries in the biology of wilms tumour. Nat Rev Urol. (2024) 21(3):158–80. 10.1038/s41585-023-00824-0 - DOI - PubMed
    1. Roehrig A, Hirsch TZ, Pire A, Morcrette G, Gupta B, Marcaillou C, et al. Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma. Nat Commun. (2024) 15(1):3031. 10.1038/s41467-024-47280-x - DOI - PMC - PubMed
    1. Li T, Kong X, He D. Epidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years. BMC Pediatr. (2025) 25(1):12. 10.1186/s12887-024-05360-3 - DOI - PMC - PubMed
    1. Ping Y, Fan Q, Zhang Y. Modulating lipid metabolism improves tumor immunotherapy. J Immunother Cancer. (2025) 13(2):e10824. 10.1136/jitc-2024-010824 - DOI - PMC - PubMed

LinkOut - more resources