CAP1-Mediated m6A modification of RRM2 suppresses tumor-associated M2 macrophage polarization and colorectal cancer growth

Tianlin Feng^#^{1

2}, Ling Lin^#¹, Xiaoya Zhou^{1

3}, Li Li^#¹, Yao Chen¹, Wenyi Zheng⁴, Qinrui Cai¹, Dongling Li^{1

5}, Jianshan Lin^{1

3}, Qianyao Wang^{1

3}, Wei Li⁶, Xiaoyuan Zheng⁷, Fan Yang⁸

Affiliations

¹ Central Laboratory of Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China.
² Pharmacy Department, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China.
³ College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
⁴ College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
⁵ National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu, 610041, China.
⁶ Department of Plastic Surgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400014, China. liwei00128@cqu.edu.cn.
⁷ Pharmacy Department, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China. XiaoyuanZheng20@126.com.
⁸ Central Laboratory of Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China. yangfanbio@cqu.edu.cn.

^# Contributed equally.

PMID: 41483049
DOI: 10.1007/s00018-025-06031-x

CAP1-Mediated m6A modification of RRM2 suppresses tumor-associated M2 macrophage polarization and colorectal cancer growth

Tianlin Feng et al. Cell Mol Life Sci. 2026.

. 2026 Jan 2.

doi: 10.1007/s00018-025-06031-x. Online ahead of print.

Authors

Affiliations

¹ Central Laboratory of Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China.
² Pharmacy Department, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China.
³ College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
⁴ College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
⁵ National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu, 610041, China.
⁶ Department of Plastic Surgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400014, China. liwei00128@cqu.edu.cn.
⁷ Pharmacy Department, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China. XiaoyuanZheng20@126.com.
⁸ Central Laboratory of Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, 400014, China. yangfanbio@cqu.edu.cn.

^# Contributed equally.

PMID: 41483049
DOI: 10.1007/s00018-025-06031-x

No abstract available

Keywords: CAP1; Colorectal cancer; M6A; Macrophage polarization; RRM2.

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Conflict of interest statement

Declarations. Ethics approval: Human study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Fourth People’s Hospital of Chong qing (Chongqing Emergency Medical Center) (Approval Number: 2025 (54)). All animal experiments were approved by the Laboratory Animal Welfare and Ethics Committee of Chongqing University Central Hospital (Approval Number: 2412004). Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing Interests: The authors have no relevant financial or non-financial interests to disclose.

References

1. Hardcastle JD, Thomas WM, Chamberlain J et al (1989) Randomised, controlled trial of faecal occult blood screening for colorectal cancer. Results for first 107,349 subjects. Lancet 1(8648):1160–1164
1. Siegel RL, Giaquinto AN (2024) Jemal cancer statistics, 2024. CA Cancer J Clin 74(1):12–49
1. Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263
1. Ono S (2013) The role of cyclase-associated protein in regulating actin filament dynamics - more than a monomer-sequestration factor. J Cell Sci 126(Pt 15):3249–3258
1. Jansen S, Collins A, Golden L et al (2014) Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. J Biol Chem 289(44):30732–30742

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CAP1-Mediated m6A modification of RRM2 suppresses tumor-associated M2 macrophage polarization and colorectal cancer growth

Affiliations

CAP1-Mediated m6A modification of RRM2 suppresses tumor-associated M2 macrophage polarization and colorectal cancer growth

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous