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. 2025 Dec;57(4):608-612.
doi: 10.3947/ic.2025.0076.

Anogenital Warts Among Men With Human Immunodeficiency Viruses in Korea: A Single-Center Retrospective Study

Sun Hee Lee  1 , Jeong Hee Han  2 , Byoung Chul Lee  2 , Hong Jae Jo  2 , Kyung Un Choi  3 , Soon Ok Lee  4 , Jeong Eun Lee  4 , Shinwon Lee  4
Affiliations

Anogenital Warts Among Men With Human Immunodeficiency Viruses in Korea: A Single-Center Retrospective Study

Sun Hee Lee et al. Infect Chemother. 2025 Dec.

Abstract

This retrospective study analyzed data from 1,192 men living with HIV (MWH) between 2002 and 2023, and identified 76 anogenital wart cases (6.4%), which were predominantly anal (n=67). Among 20 individuals with anal warts who underwent biopsy, 25% had high-grade squamous intraepithelial lesions (SILs). Of 15 individuals with low-grade SILs, one progressed to high-grade SIL after 5 years, and two developed anal cancer at 5 and 15 years. High-risk human papillomavirus genotypes were detected in 42.9% of tested specimens. These findings highlight the importance of routine screening and early detection of precancerous lesions in MWH in Korea.

Keywords: Anal cancer; HIV; Men; Squamous intraepithelial lesions; Warts.

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Conflict of interest statement

SHL is editorial board of Infect Chemother; however, he was not involved in the peer reviewer selection, evaluation, or decision process for this article. Otherwise, no potential conflicts of interest relevant to this article are reported.

Figures

Figure 1
Figure 1. A flowchart showing patient selection and clinical course.
HIV, human immunodeficiency viruses; HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion.
See this image and copyright information in PMC

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