A Pediatric Case of Becker Nevus Syndrome With Limb Overgrowth and Microvascular Malformation Associated With a Post-Zygotic ACTB Variant

Jiafang Zhu¹, Yirong Zhu^{1

2}, Zhan Qu^{1

2}, Rui Chang^{1

2}, Xiaoxi Lin^{1

2}

Affiliations

¹ Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jiafang Zhu et al. Int J Dermatol. 2026.

. 2026 Jan 5.

doi: 10.1111/ijd.70255. Online ahead of print.

Jiafang Zhu¹, Yirong Zhu^{1

2}, Zhan Qu^{1

2}, Rui Chang^{1

2}, Xiaoxi Lin^{1

2}

¹ Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

No abstract available

References

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1. E. D. Cai, B. K. Sun, A. Chiang, A. Rogers, L. Bernet, and B. Cheng, “Postzygotic Mutations in Beta‐Actin Are Associated With Becker's Nevus and Becker's Nevus Syndrome,” Journal of Investigative Dermatology 137, no. 8 (2017): 1795–1798.
1. S. Dai, H. Wang, and Z. Lin, “ACTB Mutations Analysis and Genotype‐Phenotype Correlation in Becker's Nevus,” Biomedicine 9, no. 12 (2021): 1879.
1. S. Verma, Y. K. Sharma, K. Deo, and A. Gupta, “Becker Nevus Syndrome; Probably the First Report of Concurrent Acrally Located Congenital BN, Soft Tissue Hypertrophy and Fused Carpal Bones,” Journal of the European Academy of Dermatology and Venereology 30, no. 1 (2016): 184–186.
1. K. Kunimoto, Y. Yamamoto, and M. Jinnin, “ISSVA Classification of Vascular Anomalies and Molecular Biology,” International Journal of Molecular Sciences 23, no. 4 (2022): 2358.