doi: 10.1007/BF01944693.
Induction of microsomal drug-metabolizing enzymes caused by hexobarbital
- PMID: 414931
- DOI: 10.1007/BF01944693
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Induction of microsomal drug-metabolizing enzymes caused by hexobarbital
Experientia.
.
Abstract
Hexobarbital was given to anaesthetized mice for a period of 7 h by repeated i. p. injection, first of 100 mg/kg,then several times of 50 mg/kg. A high level of hexobarbital was maintained in the liver. The activity of microsomal drug-metabolizing enzymes was induced by this treatment with hexobarbital. 30 min after a single i. p. injection of 100 mg/kg of hexobarbital, there was a significant inhibition of aminopyrine N-demethylase but none of cytochrome c and neotetrazolium reductases. Hexobarbital in vitro inhibits aminopyrine N-demethylase but not cytochrome c reductase.
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