doi: 10.1126/science.184.4133.175.
Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase
- PMID: 4150105
- DOI: 10.1126/science.184.4133.175
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Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase
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Abstract
Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.
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