Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery

Michela Consonni¹, Stefano Fresilli¹, Yuki Kotani², Eugenio Garofalo³, Nikola Bradic^{4

5}, Anna Mara Scandroglio¹, Lian Kah Ti⁶, Marco Comis⁷, Alessandro Oriani¹, Antonio Pisano⁸, Alessandro Belletti¹, Fabio Guarracino⁹, Rosario Losiggio^{10

11}, Martina Baiardo Redaelli^{12

13}, Domenico Pontillo¹, Cristina Arangino¹⁴, Alessandro Pruna¹, Francesco Federici¹⁵, Filippo D'Amico¹, Simona Silvetti¹⁶, Rosa Labanca¹, Federica Ferrod⁷, Giuseppe Pittella¹⁷, Federica Corbo¹, Marco Ranucci¹⁸, Andrea Cortegiani^{19

20}, Gianluca Paternoster^{21

22}, Tiziana Bove^{23

24}, Federico Longhini³, Fabrizio Monaco^{25

26}, Alberto Zangrillo^{1

27}, Lorenzo Piemonti^{27

28}; PROTECTION Study Group Collaborators

Affiliations

¹ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
² Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
³ Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
⁴ Clinic of Anesthesiology, Resuscitation and Intensive Care, University Hospital Dubrava, Zagreb, Croatia.
⁵ Department of Nursing, University North, Varazdin, Croatia.
⁶ Department of Anaesthesia, National University Hospital, Lower Kent Ridge Road, Singapore.
⁷ S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy.
⁸ Cardiac Anesthesia and ICU, AORN "Dei Colli", Monaldi Hospital, Naples, Italy.
⁹ Department of Cardiothoracic Anaesthesia and IC, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
¹⁰ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. losiggio.rosario@hsr.it.
¹¹ Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, Milan, 20132, Italy. losiggio.rosario@hsr.it.
¹² General and Neurosurgical Intensive Care Units, ASST Sette Laghi, Ospedale Di Circolo, Varese, Italy.
¹³ Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy.
¹⁴ Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan, Italy.
¹⁵ UOC Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy.
¹⁶ Department of Cardiac Anesthesia and Intensive Care, Ospedale Policlinico San Martino IRCCS, IRCCS Cardiovascular Network, Genova, Italy.
¹⁷ Cardiovascular Anaesthesia and ICU, San Carlo Hospital, Potenza, Italy.
¹⁸ Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
¹⁹ Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
²⁰ Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Analgesia, Palermo, Italy.
²¹ Department of Health Sciences, University of Basilicata, Potenza, Italy.
²² Anesthesia and ICU, San Carlo Hospital, Potenza, Italy.
²³ Department of Basic Biotechnological Sciences, Intensive Care Peri- Operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy.
²⁴ Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
²⁵ Departement. of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
²⁶ Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola, Bologna, Italy.
²⁷ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
²⁸ Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

PMID: 41511746
DOI: 10.1007/s40618-025-02804-0

Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery

Michela Consonni et al. J Endocrinol Invest. 2026.

. 2026 Jan 9.

doi: 10.1007/s40618-025-02804-0. Online ahead of print.

Authors

Affiliations

¹ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
² Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
³ Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
⁴ Clinic of Anesthesiology, Resuscitation and Intensive Care, University Hospital Dubrava, Zagreb, Croatia.
⁵ Department of Nursing, University North, Varazdin, Croatia.
⁶ Department of Anaesthesia, National University Hospital, Lower Kent Ridge Road, Singapore.
⁷ S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy.
⁸ Cardiac Anesthesia and ICU, AORN "Dei Colli", Monaldi Hospital, Naples, Italy.
⁹ Department of Cardiothoracic Anaesthesia and IC, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
¹⁰ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. losiggio.rosario@hsr.it.
¹¹ Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, Milan, 20132, Italy. losiggio.rosario@hsr.it.
¹² General and Neurosurgical Intensive Care Units, ASST Sette Laghi, Ospedale Di Circolo, Varese, Italy.
¹³ Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy.
¹⁴ Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan, Italy.
¹⁵ UOC Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy.
¹⁶ Department of Cardiac Anesthesia and Intensive Care, Ospedale Policlinico San Martino IRCCS, IRCCS Cardiovascular Network, Genova, Italy.
¹⁷ Cardiovascular Anaesthesia and ICU, San Carlo Hospital, Potenza, Italy.
¹⁸ Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
¹⁹ Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
²⁰ Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Analgesia, Palermo, Italy.
²¹ Department of Health Sciences, University of Basilicata, Potenza, Italy.
²² Anesthesia and ICU, San Carlo Hospital, Potenza, Italy.
²³ Department of Basic Biotechnological Sciences, Intensive Care Peri- Operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy.
²⁴ Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
²⁵ Departement. of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
²⁶ Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola, Bologna, Italy.
²⁷ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
²⁸ Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

PMID: 41511746
DOI: 10.1007/s40618-025-02804-0

No abstract available

Keywords: Acute kidney injury; Amino acids; Anesthesia; Cardiac surgery; Cardiopulmonary bypass; Renal-replacement therapy.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare that they have no conflict of interest.

References

1. American Diabetes Association Professional Practice Committee. 16. Diabetes Care in the Hospital: Standards of Care in Diabetes-2025. Diabetes Care (2025); 48(1 Suppl 1):S321-S334. https://doi.org/10.2337/DC25-S016
1. Brush JE, Siraj ES, Kemp CD et al (2019) Effect of diabetes mellitus on complication rates of coronary artery bypass grafting. Am J Cardiol 124(9):1389–1396. https://doi.org/10.1016/j.amjcard.2019.07.053 - DOI - PubMed
1. Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ (2021) Acute kidney injury. Nat Reviews Disease Primers 7(1):52. https://doi.org/10.1038/S41572-021-00284-Z - DOI - PubMed
1. National Diabetes Statistics Report | Diabetes | CDC. Center for Disease Control. May 15 (2024) Accessed October 4, 2025. https://www.cdc.gov/diabetes/php/data-research/index.html
1. Lin YF, Lin SL, Huang TM et al (2018) New-Onset diabetes after acute kidney injury requiring Dialysis. Diabetes Care 41(10):2105–2110. https://doi.org/10.2337/DC17-2409 - DOI - PubMed

Grants and funding

RF-2016-02363260/Ministero della Salute

LinkOut - more resources

Full Text Sources
- Springer

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery

Affiliations

Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources