This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comparative Study

. 1974 Mar 25;57(2):426-33.

doi: 10.1016/0006-291x(74)90948-6.

Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes

H E May, R Boose, D J Reed

PMID: 4151402
DOI: 10.1016/0006-291x(74)90948-6

Comparative Study

Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes

H E May et al. Biochem Biophys Res Commun. 1974.

. 1974 Mar 25;57(2):426-33.

doi: 10.1016/0006-291x(74)90948-6.

Authors

H E May, R Boose, D J Reed

PMID: 4151402
DOI: 10.1016/0006-291x(74)90948-6

No abstract available

PubMed Disclaimer

Similar articles

Microsomal monooxygenation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Synthesis and identification of cis and trans monohydroxylated products.
May HE, Boose R, Reed DJ. May HE, et al. Biochemistry. 1975 Oct 21;14(21):4723-30. doi: 10.1021/bi00692a025. Biochemistry. 1975. PMID: 1182112
Synthesis and identification of products derived from the metabolism of the carcinostatic 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by rat liver microsomes.
May HE, Kohlhepp SJ, Boose RB, Reed DJ. May HE, et al. Cancer Res. 1979 Mar;39(3):762-72. Cancer Res. 1979. PMID: 427763
Stereoselective monooxygenation of carcinostatic 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes.
Potter DW, Levin W, Ryan DE, Thomas PE, Reed DJ. Potter DW, et al. Biochem Pharmacol. 1984 Feb 15;33(4):609-13. doi: 10.1016/0006-2952(84)90316-2. Biochem Pharmacol. 1984. PMID: 6704177
Alkylating agents.
Connors TA. Connors TA. Top Curr Chem. 1974;52:141-71. doi: 10.1007/3-540-06873-2_16. Top Curr Chem. 1974. PMID: 4617337 Review. No abstract available.
The practical benefits of pharmacokinetics in the use of antineoplastic agents.
Erlichman C, Donehower RC, Chabner BA. Erlichman C, et al. Cancer Chemother Pharmacol. 1980;4(3):139-45. doi: 10.1007/BF00254011. Cancer Chemother Pharmacol. 1980. PMID: 6994913 Review. No abstract available.

See all similar articles

Cited by

Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.
Ahmed AE, Grissom M, el-Azhary R, Haque A, Boor PJ, Costanzi J. Ahmed AE, et al. Cancer Chemother Pharmacol. 1987;19(2):103-8. doi: 10.1007/BF00254560. Cancer Chemother Pharmacol. 1987. PMID: 3105904
Chemopotentiation of CCNU metabolites by misonidazole.
Mulcahy RT. Mulcahy RT. Br J Cancer. 1985 May;51(5):733-5. doi: 10.1038/bjc.1985.110. Br J Cancer. 1985. PMID: 3994915 Free PMC article. No abstract available.
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Siemann DW. Siemann DW. Br J Cancer. 1982 Feb;45(2):272-81. doi: 10.1038/bjc.1982.43. Br J Cancer. 1982. PMID: 6460517 Free PMC article.
Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.
Levin VA, Kabra PA, Freeman-Dove MA. Levin VA, et al. Cancer Chemother Pharmacol. 1978;1(4):233-42. doi: 10.1007/BF00257156. Cancer Chemother Pharmacol. 1978. PMID: 750110
Treatment of malignant brain tumours with ACNU and phenobarbital: continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital.
Yumitori K, Handa H, Teraura T, Yamashita J. Yumitori K, et al. Acta Neurochir (Wien). 1984;70(3-4):155-68. doi: 10.1007/BF01406646. Acta Neurochir (Wien). 1984. PMID: 6585127

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science