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. 1974 Mar;37(3):275-81.
doi: 10.1136/jnnp.37.3.275.

Phenytoin intoxication induced by sulthiame in epileptic patients

G W Houghton, A Richens

Phenytoin intoxication induced by sulthiame in epileptic patients

G W Houghton et al. J Neurol Neurosurg Psychiatry. 1974 Mar.

Abstract

Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.

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References

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