Updated result from the phase 2 PHAROS study: has the sustained efficacy and tolerability of encorafenib plus binimetinib been demonstrated in patients with BRAF V600E-mutant metastatic non-small-cell lung cancer?
- PMID: 41522121
- PMCID: PMC12780439
- DOI: 10.21037/jtd-2025-1908
Updated result from the phase 2 PHAROS study: has the sustained efficacy and tolerability of encorafenib plus binimetinib been demonstrated in patients with BRAF V600E-mutant metastatic non-small-cell lung cancer?
Keywords: BRAF V600E; binimetinib; encorafenib; non-small cell lung cancer (NSCLC).
Conflict of interest statement
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-1908/coif). K.Y. receives funding from Daiichi Sankyo Co., Ltd., and Honoraria for lectures from Chugai Pharmaceutical Co., Ltd., AstraZeneca, Amgen Inc., and Pfizer R&D Japan G.K. He has issued and pending patents with Daiichi Sankyo Co., Ltd. The author has no other conflicts of interest to declare.
Comment on
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Updated Efficacy and Safety From the Phase 2 PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic NSCLC-A Brief Report.J Thorac Oncol. 2025 Oct;20(10):1538-1547. doi: 10.1016/j.jtho.2025.05.023. Epub 2025 Jun 4. J Thorac Oncol. 2025. PMID: 40480428 Clinical Trial.
References
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- National Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology: non-small cell lung cancer. version 8; 2025.
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- Dummer R, Ascierto PA, Gogas HJ, et al. Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2018;19:603-15. - PubMed
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