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. 1973 Oct;49(2):364-7.
doi: 10.1111/j.1476-5381.1973.tb08385.x.

Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves

P Eyre, P W Wells

Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves

P Eyre et al. Br J Pharmacol. 1973 Oct.

Abstract

Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.

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References

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