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Case Reports
. 1978 Mar;28(3):290-4.
doi: 10.1212/wnl.28.3.290.

Marchiafava-Bignami disease

A H Koeppen, K D Barron
Case Reports

Marchiafava-Bignami disease

A H Koeppen et al. Neurology. 1978 Mar.

Abstract

Marchiafava-Bignami disease was diagnosed postmortem in a 39-year-old man who drank excessive amounts of white port wine. This is the fifth report of the disease in a native North-American with no Italian ancestry. The lesion involved the corpus callosum and hippocampal commissure but spared the anterior commissure, middle cerebellar peduncles, optic chiasm, and centrum semiovale. Wernicke-Korsakoff encephalopathy and pellagroid neuronal changes were also present.

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