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. 1978 Jan 31;56(1):37-40.
doi: 10.1007/BF00571405.

On the interaction of drugs with the cholinergic nervous system. II. Cross-tolerance between phencyclidine derivatives and cholinergic drugs

I Pinchasi, S Maayani, Y Egozi, M Sokolovsky

On the interaction of drugs with the cholinergic nervous system. II. Cross-tolerance between phencyclidine derivatives and cholinergic drugs

I Pinchasi et al. Psychopharmacology (Berl). .

Abstract

A symmetrical cross-tolerance was found between two phencyclidine derivatives--phencyclidine and cyclohexamine--and also between two cholinergic drugs--physostigmine and oxotremorine. On the other hand, mice rendered tolerant to the phencyclidine derivatives showed cross-tolerance to these cholinergic drugs, but no cross-tolerance was observed in the opposite direction. The applicability of such experiments to the elucidation of neurochemical interactions of centrally acting drugs is discussed.

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References

    1. Psychopharmacologia. 1975 Oct 31;44(2):139-45 - PubMed
    1. Psychopharmacology (Berl). 1977 Nov 24;55(1):43-8 - PubMed
    1. Psychopharmacologia. 1966;9(5):434-46 - PubMed
    1. Psychopharmacologia. 1962 Mar 12;3:1-14 - PubMed
    1. Life Sci I. 1970 Oct 15;9(20):1141-52 - PubMed

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