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. 1974 Aug 31;3(5930):554-6.
doi: 10.1136/bmj.3.5930.554.

Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man

D C Carter, J A Forrest, M Werner, R C Heading, J Park, D J Shearman

Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man

D C Carter et al. Br Med J. .

Abstract

Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.

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