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. 1974 Nov 22;186(4165):738-9.
doi: 10.1126/science.186.4165.738.

Gamma-aminobutyric acid effects on pituitary gonadotropin secretion

J G Ondo

Gamma-aminobutyric acid effects on pituitary gonadotropin secretion

J G Ondo. Science. .

Abstract

Gamma-aminobutyric acid (GABA) injected into the third ventricle of male rats promotes the release of pituitary luteinizing hormone (LH) but not follicle-stimulating hormone. When GABA was injected directly into the pituitary it was ineffective in promoting LH release. This evidence suggests that GABA may play a role in controlling the discharge of hypothalamic luteinizing hormone releasing factor.

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