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Comparative Study
. 1974 Nov;71(11):4361-5.
doi: 10.1073/pnas.71.11.4361.

Amino-acid sequence of NADP-specific glutamate dehydrogenase of neurospora crassa

J C Wootton, G K Chambers, A A Holder, A J Baron, J G Taylor, J R Fincham, K M Blumenthal, K Moon, E L Smith
Comparative Study

Amino-acid sequence of NADP-specific glutamate dehydrogenase of neurospora crassa

J C Wootton et al. Proc Natl Acad Sci U S A. 1974 Nov.

Abstract

A tentative primary structure of the NADP-specific glutamate dehydrogenase [L-glutamate: NADP oxidoreductase (deaminating), EC 1.4.1.4] from Neurospora crassa has been determined. The proposed sequence contains 452 amino-acid residues in each of the identical subunits of the hexameric enzyme. Comparison of the sequence with that of the bovine liver enzyme reveals considerable homology in the amino-terminal portion of the chain, including the vicinity of the reactive lysine, with only shorter stretches of homology within the carboxyl-terminal regions. The significance of this distribution of homologous regions is discussed.

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