The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices
- PMID: 4155974
- PMCID: PMC1776773
- DOI: 10.1111/j.1476-5381.1974.tb10687.x
The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices
Abstract
Indoramin has been tested for its ability to inhibit the uptake of tritiated (-)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other alpha-blocking agents and tricycic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigators,
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