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. 1974 Jul;51(3):467-9.
doi: 10.1111/j.1476-5381.1974.tb10687.x.

The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices

The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices

R F Sugden. Br J Pharmacol. 1974 Jul.

Abstract

Indoramin has been tested for its ability to inhibit the uptake of tritiated (-)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other alpha-blocking agents and tricycic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigators,

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References

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