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. 1974 Dec;27(6):989-1007.

Immunological disease induced by injecting F1 lymphoid cells into certain parental strains

E Simpson, S O'Hopp, M Harrison, D Mosier, K Melief, H Cantor

Immunological disease induced by injecting F1 lymphoid cells into certain parental strains

E Simpson et al. Immunology. 1974 Dec.

Abstract

Injection of neonatal Balb/c or C57Bl/6 mice with C57Bl/6 x Balb/c)F1 lymphoid cells leads to transient chimerism and runting, and to splenomegaly, deficient T-cell function and a gradual replacement of lymphoid organs with abnormal reticular cells. Activated MuLV can be isolated from such mice. It is proposed that either graft-versus-host or host-versus-graft allogeneic reactivity activates endogenous MuLV virus, which then causes functional and morphological abnormalities in the lymphoid organs.

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