Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2026 Mar 1;83(3):318-320.
doi: 10.1001/jamapsychiatry.2025.4347.

Alzheimer Disease-Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

Michael J C Bray  1 , Jacob S Shaw  1 , Christopher B Morrow  1 , Chiadi U Onyike  1 ; Alzheimer’s Disease Neuroimaging Initiative
Collaborators, Affiliations

Alzheimer Disease-Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

Michael J C Bray et al. JAMA Psychiatry. .
No abstract available

Plain language summary

This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Morrow reported grants from the US National Institutes of Health (National Institute on Aging: K23AG088248, L30AG083912) during the conduct of the study. Dr Onyike reported grants from Alector and Denali Therapeutics and consulting fees from BioHaven, Eli Lilly, Otsuka, Reata Pharmaceuticals, Sanofi, and Zevra Therapeutics outside the submitted work. No other disclosures were reported.

References

    1. Peters ME, Schwartz S, Han D, et al. Neuropsychiatric symptoms as predictors of progression to severe Alzheimer’s dementia and death: the Cache County Dementia Progression Study. Am J Psychiatry. 2015;172(5):460-465. doi: 10.1176/appi.ajp.2014.14040480 - DOI - PMC - PubMed
    1. Fuller JT, Choudhury TK, Lowe DA, Balsis S; Alzheimer’s Disease Neuroimaging Initiative . Hallucinations and delusions signal Alzheimer’s associated cognitive dysfunction more strongly compared to other neuropsychiatric symptoms. J Gerontol B Psychol Sci Soc Sci. 2020;75(9):1894-1904. doi: 10.1093/geronb/gbz032 - DOI - PMC - PubMed
    1. Almeida FC, Jesus T, Coelho A, et al. Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology. Neurobiol Aging. 2024;138:10-18. doi: 10.1016/j.neurobiolaging.2024.02.013 - DOI - PubMed
    1. Gomar JJ, Tan G, Halpern J, Gordon ML, Greenwald B, Koppel J. Increased retention of tau PET ligand [18F]-AV1451 in Alzheimer’s Disease Psychosis. Transl Psychiatry. 2022;12(1):82. doi: 10.1038/s41398-022-01850-z - DOI - PMC - PubMed
    1. Koppel J, Acker C, Davies P, et al. Psychotic Alzheimer’s disease is associated with gender-specific tau phosphorylation abnormalities. Neurobiol Aging. 2014;35(9):2021-2028. doi: 10.1016/j.neurobiolaging.2014.03.003 - DOI - PMC - PubMed

LinkOut - more resources