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. 1974 Oct;144(1):29-35.
doi: 10.1042/bj1440029.

Putrescine catabolism in mammalian brain

N Seiler, M J Al-Therib

Putrescine catabolism in mammalian brain

N Seiler et al. Biochem J. 1974 Oct.

Abstract

In contrast with putrescine (1,4-diaminobutane), which is a substrate of diamine oxidase, monoacetylputrescine is oxidatively deaminated both in vitro and in vivo by monoamine oxidase. The product of this reaction is N-acetyl-gamma-aminobutyrate. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle.

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