Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci
- PMID: 4157335
- PMCID: PMC444661
- DOI: 10.1128/AAC.6.4.411
Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci
Abstract
Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.
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