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Review
. 2026 Jan 22:172:116249.
doi: 10.1016/j.intimp.2026.116249. Online ahead of print.

Recent research progress in structural optimization and cancer treatment of novel selective FGFR inhibitors (2020-2025)

Rongfei Liu  1 , Jinghui Qi  1 , Yue Liu  2 , Mingyue Hou  1 , Mingyu Zhang  1 , Xuan An  1 , Jinxing Hu  3
Affiliations
Review

Recent research progress in structural optimization and cancer treatment of novel selective FGFR inhibitors (2020-2025)

Rongfei Liu et al. Int Immunopharmacol. .

Abstract

Abnormalities in protein tyrosine kinases (PTKs) are one of the primary drivers of cancer. As a receptor subfamily, fibroblast growth factor receptors (FGFRs) comprise four subtypes-FGFR1 to FGFR4. Their abnormal intracellular expression is a significant cause of tumorigenesis, making FGFRs key therapeutic targets in cancer treatment. This paper primarily summarizes the latest research advances in FGFR inhibitors, aiming to provide insights for future design and synthesis studies of FGFR inhibitors.

Keywords: Cancer therapy; FGFR; Inhibitor; Small-molecule derivatives; Structural optimization.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.