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. 1978 Jan;19(1):35-41.
doi: 10.1007/BF01685764.

Trout hepatic enzyme activation of aflatoxin B1 in a mutagen assay system and the inhibitory effect of PCBs1

W T Stott, R O Sinnhuber

Trout hepatic enzyme activation of aflatoxin B1 in a mutagen assay system and the inhibitory effect of PCBs1

W T Stott et al. Bull Environ Contam Toxicol. 1978 Jan.

Abstract

In summary, it was demonstrated that the trout PMF may be successfully employed in the Ames mutagen assay method by utilization of proper salts solution and a metabolic preincubation period at 25 degrees C. It has also been observed that, unlike the rat, pretreatment of rainbow trout with various PCBs decrease the mutagen assay response to AFB.

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References

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    1. Chem Biol Interact. 1974 Nov;9(5):341-50 - PubMed
    1. Cancer Res. 1976 Jun;36(6):2040-5 - PubMed
    1. Bull Environ Contam Toxicol. 1975 Apr;13(4):456-63 - PubMed
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