Non-spatial memory after selective prefrontal lesions in monkeys

Abstract

Separate groups of monkeys were trained on delayed object alternation, delayed object matching, and delayed color matching, after which half the animals in each group received lesions of the cortex in the principal sulcus, and the other half, lesions of the inferior frontal convexity. The inferior convexity lesions produced severe and lasting impairments on all three tasks, perhaps as a result of the perseverative disorder that has been associated with damage to this region. By contrast, the principal sulcus lesions, which yield such severe deficits on spatial memory tasks, led to only small, transient disruptions on each of the three non-spatial tasks. According to these results, the non-spatial memory deficits that have been found after unrestricted lateral prefrontal lesions are due mainly to damage below the principal sulcus in the inferior prefrontal cortex. The function of the tissue in the principal sulcus itself, on the other hand, appears so far to be limited largely to the spatial modality.