Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1965 Aug;9(2):177-91.

The effects of antibodies on cells. 3. Studies on the interaction of rat liver mitochondria and lysosomes with antibody and complement

D C Dumonde, D B Roodyn, P H Prose

The effects of antibodies on cells. 3. Studies on the interaction of rat liver mitochondria and lysosomes with antibody and complement

D C Dumonde et al. Immunology. 1965 Aug.

Abstract

Complement-fixing and precipitating antibodies to mitochondrial and lysosomal fractions of rat liver were induced in rabbits. The incubation of these subcellular fractions with ferritin-labelled antibody revealed localization of the antibody on mitochondria and lysosomes, but no specific morphological effect of antibody and complement. Incubation of the cell fractions with antibody and complement did not impair the efficiency of mitochondrial oxidative phosphorylation or affect the latency and sedimentation characteristics of lysosomal acid phosphatase. The results are discussed in relation to the action of antibody and complement on cells and to possible mechanisms of tissue damage in auto-immunity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Biophys Biochem Cytol. 1960 Oct;8:413-22 - PubMed
    1. Biochem J. 1953 Oct;55(3):530-44 - PubMed
    1. Biochem J. 1957 Dec;67(4):558-72 - PubMed
    1. J Exp Med. 1955 May 1;101(5):557-76 - PubMed
    1. Nature. 1964 Apr 18;202:251-2 - PubMed

LinkOut - more resources