Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1965 Oct;9(4):303-9.

The effect of decomplementation on delayed-type hypersensitive reactions to a conjugated antigen in rats

T Neveu, G Biozzi

The effect of decomplementation on delayed-type hypersensitive reactions to a conjugated antigen in rats

T Neveu et al. Immunology. 1965 Oct.

Abstract

A method has been described for quantitative measurement of the intensity of cutaneous delayed hypersensitive reactions in rats. This method is based on the measurement of the weight of skin infiltration at the site of cutaneous reaction.

In vivo decomplementation of rats with antigen—antibody complexes or aggregated γ-globulin is accompanied by a decrease in delayed hypersensitivity responsiveness.

When the level of serum complement is reduced by 90 per cent delayed hypersensitive reactions are completely suppressed.

The results presented, although suggestive, do not provide a definite proof of the role of complement in the development of delayed hypersensitive reactions in the skin.

PubMed Disclaimer

References

    1. J Exp Med. 1963 Jun 1;117:965-81 - PubMed
    1. J Exp Med. 1963 Jun 1;117:951-64 - PubMed
    1. J Immunol. 1962 May;88:595-9 - PubMed
    1. J Exp Med. 1961 Dec 1;114:997-1022 - PubMed
    1. J Immunol. 1962 Dec;89:861-7 - PubMed

LinkOut - more resources