Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1965;6(3):249-60.
doi: 10.1186/BF03547082.

Passage of I-131-albumin and I-125-gamma globulin into the small intestine of calves

K Nielsen, J Dich

Passage of I-131-albumin and I-125-gamma globulin into the small intestine of calves

K Nielsen et al. Acta Vet Scand. 1965.

Abstract
in English, German, Swedish

Intestinal transfer of I131-albumin and I125-gamma globulin was studied in 5 calves fitted with re-entrant intestinal loops. The passage of the two proteins across the intestinal wall proved highly variable (cf. Table II). However, the transfer of I131-albumin and I125-gamma globulin was of the same order of magnitude, which is taken as evideńce of similar transfer mechanisms of albumin and gamma globulin, in spite of different molecular weights. Instillations of hypertonic magnesium sulphate solution and of intestinal digesta were followed by increased transfer rates. It appears, therefore, that the passage of digesta will influence the transfer of proteins along the gut. It is emphasized that quantitation of the transfer as related to total catabolism of plasma proteins is subject to considerable inaccuracy.

bei Kälbern.

Der intestinale Durchtritt von J131-Albumin und J125-Gammaglobulin bei 5 Kälbern mit isolierten Darmsegmenten wurde untersucht. Ausserordentliche Variation wurde festgestellt (Tabelle II), wogegen eine Vergleichung zwischen dem Durchtritt von Albumin und Gammaglobulin erwies, dass dieser von gleicher Grösse war. Dies wird als Schein daran gehalten, dass der Durchtritt von beiden Eiweissstoffen dem selben metabolischen Muster folgt, trotz verschiedenes Molekülgewicht. Instillationen von hypertonischen Magnesiumsulfatlösungen und von Ingesta rufen eine Steigerung im Durchtritt hervor. Es ist deshalb sehr wahrscheinlich, dass die Darmpassage für den Durchtritt von Plasmaproteinen dem Darm entlang eine Rolle spielt. Es wird betönt, dass die quantitative Berechnung des Durchtrittes in Relation zum totalen Eiweiss-Katabolismus unsicher ist.

Den intestinale udskillelse af J131-albumin og J125-gammaglobulin er undersøgt hos 5 kalve forsynede med isolerede tarmslynger. Der fandtes overordentlig stor variation i udskillelsen (tabel II), hvorimod en sammenligning mellem udskillelsen af albumin og gammaglobulin viste, at denne var af samme størrelsesorden. Dette er taget som udtryk for, at udskillelsen af de to proteinstoffer følger samme metaboliske mønster trods den forskellige molekylvægt. Instillation af hypertoniske magnesiumsulfatopløsninger samt af tyndtarmsindhold efterfulgtes af en forøget udskillelse af begge plasmaproteiner. Det må derfor anses for sandsynligt, at tarmpassagen spiller en rolle for udskillelsen af serumproteiner ned gennem tarmen. Det understreges, at beregninger af udskillelsens betydning i forhold til proteinnedbrydningen som helhed, er underkastet betydelig usikkerhed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Andersen, S. B., J. Glenert & K. Wallevik: Turnover and intestinal degradation of gamma globulin in the dog. I: Peeters, H.: Protides of the biological fluids. Proc. 11th colloquium, Brügge 1963. Elsevier Publishing Co., Amsterdam 1964, p. 272.
    1. Armstrong F B, Margen S, Tarver H. Plasma protein VII. Site of degradation of serum albumin. Proc. Soc. exp. Biol. (N. Y.) 1960;103:592. doi: 10.3181/00379727-103-25606. - DOI - PubMed
    1. Ash R W. Gastrointestinal re-entrant cannulae for studies of digestion in sheep. Anim. Prod. 1962;4:309.
    1. Barandun S, Nusslé D, Witschi H P, Buser F. Untersuchungen über den Durchtritt von Plasmaproteinen in das Darmlumen bei gesunden Kindern. Schweiz, med. Wschr. 1962;92:316.
    1. Birke G, Gullberg R, Liljedahl S.-O, Olhagen B, Plantin L.-O, Wetterfors J. Studier av albumin läkage i ventrikelen. Nord. Med. 1960;64:1179.

MeSH terms

Substances

LinkOut - more resources