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. 1966 Feb 1;123(2):347-64.
doi: 10.1084/jem.123.2.347.

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus

A L Notkins, S E Mergenhagen, A A Rizzo, C Scheele, T A Waldmann

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus

A L Notkins et al. J Exp Med. .

Abstract

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.

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