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Review
. 2026 Jan 28;49(1):165.
doi: 10.1007/s10143-025-04121-9.

Melatonin in glioblastoma therapy: clinical promise and mechanistic insights from bench to bedside

Omar Alomari  1 , Beyzanur Güney  2 , Rana Al Juhmani  3 , Bassel Alrabadi  4 , Muhammed Edib Mokresh  2 , Hatice Odabas  5 , Tasneem Alomari  6 , Russel J Reiter  7
Affiliations
Review

Melatonin in glioblastoma therapy: clinical promise and mechanistic insights from bench to bedside

Omar Alomari et al. Neurosurg Rev. .
No abstract available

Keywords: Apoptosis; Drug synergism; GBM; MLT; Tumor microenvironment.

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Conflict of interest statement

Declarations. Ethics approval: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable.

References

    1. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro-oncology 23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106 - DOI - PubMed - PMC
    1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl J Med 352:987–96. https://doi.org/10.1056/NEJMoa043330 - DOI - PubMed
    1. Louis DN et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109 - DOI - PubMed - PMC
    1. Dirks PB (2010) Brain tumor stem cells: the cancer stem cell hypothesis writ large. Mol Oncol 4:420–430. https://doi.org/10.1016/j.molonc.2010.08.001 - DOI - PubMed - PMC
    1. Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J (2016) Glioma stem cells: signaling, microenvironment, and therapy. Stem Cells Int 2016:1–10. https://doi.org/10.1155/2016/7849890 - DOI

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