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. 1966 May 27;152(3726):1274-6.
doi: 10.1126/science.152.3726.1274.

Effect of interferon on early interferon production

H B Levy, C E Buckler, S Baron

Effect of interferon on early interferon production

H B Levy et al. Science. .

Abstract

Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.

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