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. 1966 Jul 1;153(3731):75-6.
doi: 10.1126/science.153.3731.75.

Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture

G F Winkler, B G Arnason

Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture

G F Winkler et al. Science. .

Abstract

Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.

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