Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2026 Jan 30;138(3):e327969.
doi: 10.1161/CIRCRESAHA.125.327969. Epub 2026 Jan 29.

When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA

Gage M Stuttgen  1 , Michael Chang  1 , Jesse W Williams  1
Affiliations
Editorial

When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA

Gage M Stuttgen et al. Circ Res. .
No abstract available

Keywords: Editorials; atherosclerosis; inflammation; macrophages; monocytes.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1:
Figure 1:. Olfr2 guides monocyte recruitment to the inflamed aortic wall during AAA.
Olfr2-expression corresponds with increased CX3CR1 on blood monocytes and enhances recruitment to the vascular wall in experimental AAA. Additionally, exogenous Olfr2 agonism with octanal promoted AAA lesion formation. Olfr2 blockade (citral) or CX3CR1 inhibition (JSM 17–2) showed attenuated monocyte recruitment and AAA pathology.
See this image and copyright information in PMC

Comment on

  • Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.
    Schelemei P, Picard FSR, Park Y, Wollnitzke P, Nemade H, Lechner SK, Mehrkens D, Arkenberg P, Köbele AC, Wrobel J, Martinez Lagunas K, Wagner E, Guthoff H, Hof A, Cummings K, Al Zaidi M, Zimmer S, Roy J, Lindquist Liljeqvist M, Wolf D, Riffelmacher T, Ibing W, Wagenhäuser MU, Schelzig H, Levkau B, Flögel U, Gerdes N, Karimpour M, Hillmer AM, Sengle G, Megens RTA, Weber C, Orecchioni M, Baldus S, Mollenhauer M, Winkels H. Schelemei P, et al. Circ Res. 2026 Jan 30;138(3):e326591. doi: 10.1161/CIRCRESAHA.125.326591. Epub 2025 Dec 31. Circ Res. 2026. PMID: 41473953

References

    1. Sakalihasan N, Michel J-B, Katsargyris A, Kuivaniemi H, Defraigne J-O, Nchimi A, Powell JT, Yoshimura K, Hultgren R. Abdominal aortic aneurysms. Nature Reviews. Disease Primers. 2018;4:34. - PubMed
    1. Golledge J, Thanigaimani S, Powell JT, Tsao PS. Pathogenesis and management of abdominal aortic aneurysm. European Heart Journal. 2023;44:2682–2697. - PMC - PubMed
    1. Raffort J, Lareyre F, Clément M, Hassen-Khodja R, Chinetti G, Mallat Z. Monocytes and macrophages in abdominal aortic aneurysm. Nature Reviews. Cardiology. 2017;14:457–471. - PubMed
    1. Schelemei P, Picard FSR, Park Y, Wollnitzke P, Nemade H, Lechner SK, Mehrkens D, Arkenberg P, Koebele AC, Wrobel J, et al. Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm. Circulation Research. 2026:138: xx–xxx. - PubMed
    1. Mildner A, Kim K-W, Yona S. Unravelling monocyte functions: from the guardians of health to the regulators of disease. Discovery Immunology. 2024;3:kyae014. - PMC - PubMed

LinkOut - more resources