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Comparative Study
. 1978 Mar;52(2):343-8.
doi: 10.1530/jrf.0.0520343.

Pituitary responsiveness to LH-RH and TRH and the effects of progesterone or progesterone and oestradiol treatment in anoestrous sheep

P J Wright, G Jenkin, R B Heap, D E Walters
Comparative Study

Pituitary responsiveness to LH-RH and TRH and the effects of progesterone or progesterone and oestradiol treatment in anoestrous sheep

P J Wright et al. J Reprod Fertil. 1978 Mar.

Abstract

Pituitary responsiveness to 200 microgram synthetic LH-RH and to 10 microgram TRH was determined in anoestrous sheep before and after treatment for 3 weeks with progesterone (100 mg/day), or oestradiol (250 microgram/day) plus progesterone (100 mg/day). There was a marked decrease in pituitary responsiveness to LH-RH after progesterone (P is less than 0.01), or oestradiol plus progesterone (P is less than 0.01) treatments, and an increase in response to TRH after oestradiol plus progesterone (P is less than 0.01) treatment. The results demonstrate selective and simultaneous feedback effects of oestradiol and progesterone on pituitary responsiveness to two hypothalamic releasing hormones.

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