Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Feb 1;125(2):303-16.
doi: 10.1084/jem.125.2.303.

Heavy chain subclasses of human gamma G-globulin. Serum distribution and cellular localization

G M Bernier, R E Ballieux, K T Tominaga, F W Putnam

Heavy chain subclasses of human gamma G-globulin. Serum distribution and cellular localization

G M Bernier et al. J Exp Med. .

Abstract

Two antigenic types of naturally occurring proteins related to the papain produced F(c) fragment of gammaG-globulin have been studied. Most normal and myeloma gammaG-globulins are related to one or the other of these proteins, based on antigenic and structural characteristics of their heavy chain. Molecules bearing the determinant "Cr" are approximately 10 times as abundant as those bearing the determinant termed "Zu" in pools of normal gammaG-globulin and among a large group of gammaG-myeloma globulins. Both populations have properties of typical gammaG-globulin antibodies. Splenic cells, stained for these two populations with specific fluorescent antibody preparations, are found to contain one or the other of the two populations of gammaG-globulin, but not both. Approximately 10 times as many cells contain the Cr determinant as contain the Zu determinant.

PubMed Disclaimer

References

    1. Science. 1966 Jun 10;152(3728):1513-6 - PubMed
    1. Immunology. 1964 Sep;7:500-6 - PubMed
    1. Science. 1966 Aug 26;153(3739):1007-8 - PubMed
    1. J Exp Med. 1963 Jan 31;117(2):213-30 - PubMed
    1. Nature. 1963 Dec 21;200:1180-1 - PubMed

Substances